Cell Senescence Entries for LEO1

Cell Types
Lung fibroblast
Cell Lines
2BS
Cancer Cell?
No
Method
Overexpression
Type of senescence
Replicative
Senescence Effect
Unclear
Primary Reference
Zhao et al. (2005) Expression of the Leo1-like domain of replicative senescence down-regulated Leo1-like (RDL) protein promotes senescence of 2BS fibroblasts. FASEB J 19(6)521-32 (PubMed)

LEO1 Gene Information

HGNC symbol
LEO1 
Aliases
 
Common name
LEO1 homolog, Paf1/RNA polymerase II complex component 
Entrez Id
123169
Description
LEO1, parafibromin (CDC73; MIM 607393), CTR9 (MIM 609366), and PAF1 (MIM 610506) form the PAF protein complex that associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008].

LEO1 Ontologies

Gene Ontology
Process: GO:6368; transcription elongation from RNA polymerase II promoter
GO:16570; histone modification
GO:16055; Wnt signaling pathway
GO:6378; mRNA polyadenylation
GO:10390; histone monoubiquitination
GO:32968; positive regulation of transcription elongation from RNA polymerase II promoter
GO:45638; negative regulation of myeloid cell differentiation
GO:19827; stem cell population maintenance
GO:33523; histone H2B ubiquitination
GO:31442; positive regulation of mRNA 3'-end processing
GO:1711; endodermal cell fate commitment
And 1 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:1650; fibrillar center
GO:5813; centrosome
GO:16593; Cdc73/Paf1 complex
Function: GO:5515; protein binding
GO:1990269; RNA polymerase II C-terminal domain phosphoserine binding
Show all GO terms

Homologs of LEO1 in Model Organisms

Caenorhabditis elegans
B0035.11
Danio rerio
leo1
Drosophila melanogaster
Atu
Mus musculus
Leo1
Rattus norvegicus
Leo1
Saccharomyces cerevisiae
LEO1
Schizosaccharomyces pombe
SPBC13E7.08c

External links

OMIM
610507
Ensembl
ENSG00000166477
Entrez Gene
123169
UniGene
567662
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LEO1
GeneCards
LEO1