Cell Senescence Entries for LIMA1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Succoio et al. (2016) Proteomic analysis reveals novel common genes modulated in both replicative and stress-induced senescence. J Proteomics 128(2)18-29 (PubMed)

LIMA1 Gene Information

HGNC symbol
LIMA1 
Aliases
EPLIN 
Common name
LIM domain and actin binding 1 
Entrez Id
51474
Description
This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011].

LIMA1 Ontologies

Gene Ontology
Process: GO:51017; actin filament bundle assembly
GO:30835; negative regulation of actin filament depolymerization
GO:6629; lipid metabolic process
GO:8202; steroid metabolic process
GO:8203; cholesterol metabolic process
GO:16477; cell migration
GO:42632; cholesterol homeostasis
GO:31529; ruffle organization
GO:30299; intestinal cholesterol absorption
Cellular component: GO:5886; plasma membrane
GO:5925; focal adhesion
GO:15629; actin cytoskeleton
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5856; cytoskeleton
GO:30054; cell junction
GO:32154; cleavage furrow
GO:1726; ruffle
GO:1725; stress fiber
And 3 more GO terms
Function: GO:46872; metal ion binding
GO:51015; actin filament binding
GO:3779; actin binding
GO:5515; protein binding
GO:45296; cadherin binding
GO:3785; actin monomer binding
Show all GO terms

Homologs of LIMA1 in Model Organisms

Danio rerio
lima1
Drosophila melanogaster
CG33521
Mus musculus
Lima1
Rattus norvegicus
Lima1

External links

OMIM
608364
Ensembl
ENSG00000050405
Entrez Gene
51474
UniGene
525419
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LIMA1
GeneCards
LIMA1