Cell Senescence Entries for LIMK1

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

LIMK1 Gene Information

HGNC symbol
LIMK1 
Aliases
LIMK 
Common name
LIM domain kinase 1 
Entrez Id
3984
Description
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011].

LIMK1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:45773; positive regulation of axon extension
GO:30036; actin cytoskeleton organization
GO:7399; nervous system development
GO:7165; signal transduction
GO:7266; Rho protein signal transduction
GO:38096; Fc-gamma receptor signaling pathway involved in phagocytosis
GO:51496; positive regulation of stress fiber assembly
GO:51444; negative regulation of ubiquitin-protein transferase activity
GO:32233; positive regulation of actin filament bundle assembly
And 1 more GO terms
Cellular component: GO:16607; nuclear speck
GO:5829; cytosol
GO:43229; intracellular organelle
GO:5737; cytoplasm
GO:5634; nucleus
GO:5856; cytoskeleton
GO:42995; cell projection
GO:43005; neuron projection
GO:30027; lamellipodium
GO:5925; focal adhesion
GO:16020; membrane
And 1 more GO terms
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:31072; heat shock protein binding
And 1 more GO terms
Show all GO terms

Homologs of LIMK1 in Model Organisms

Danio rerio
limk1a
Mus musculus
Limk1
Rattus norvegicus
Limk1

External links

OMIM
601329
Ensembl
ENSG00000106683
Entrez Gene
3984
UniGene
647035
1000 Genomes
1000 Genomes
HPRD
GenAtlas
LIMK1
GeneCards
LIMK1