Cell Senescence Entries for LIN54
- Cell Types
- Foreskin fibroblast
- Cell Lines
- BJ
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Hauser et al. (2012) Loss of LIN9, a member of the DREAM complex, cooperates with SV40 large T antigen to induce genomic instability and anchorage-independent growth. Oncogene 31(14)1859-68 (PubMed)
LIN54 Gene Information
- HGNC symbol
- LIN54
- Aliases
- CXCDC1; DKFZp686L1814; JC8.6; MIP120; TCX1
- Common name
- lin-54 DREAM MuvB core complex component
- Entrez Id
- 132660
- Description
- LIN54 is a component of the LIN, or DREAM, complex, an essential regulator of cell cycle genes (Schmit et al., 2009 [PubMed 19725879]).[supplied by OMIM, Dec 2010].
LIN54 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:16584; nucleosome positioning
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
Show all GO termsFunction: GO:46872; metal ion binding
GO:3677; DNA binding
GO:5515; protein binding
GO:3680; minor groove of adenine-thymine-rich DNA binding
GO:1067; transcription regulatory region nucleic acid binding
Homologs of LIN54 in Model Organisms
External links
- OMIM
- 613367
- Ensembl
- ENSG00000189308
- Entrez Gene
- 132660
- UniGene
- 96952
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- LIN54
- GeneCards
- LIN54