The LRRK2 gene and its putative association with human ageing

Cell Senescence Entries for LRRK2

Cell Types: Bone marrow neuroblastoma
Cell Lines: SH-SY5Y
Cancer Cell?: Yes
Method: Mutation
Type of senescence: Unclear
Senescence Effect: Unclear
Primary Reference: Ho et al. (2020) Upregulation of the p53-p21 pathway by G2019S LRRK2 contributes to the cellular senescence and accumulation of α-synuclein. Cell Cycle 18(4)467-475 (PubMed)

HGNC symbol: LRRK2
Aliases: DKFZp434H2111; FLJ45829; PARK8; RIPK7; ROCO2
Common name: leucine rich repeat kinase 2
Entrez Id: 120892
Description: This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq, Jul 2008].

Gene Ontology

Process:	GO:6468; protein phosphorylation GO:16310; phosphorylation GO:30154; cell differentiation GO:6470; protein dephosphorylation GO:6914; autophagy GO:165; MAPK cascade GO:46777; protein autophosphorylation GO:7165; signal transduction GO:42391; regulation of membrane potential GO:70973; protein localization to endoplasmic reticulum exit site GO:10508; positive regulation of autophagy
	And 94 more GO terms

Cellular component:	GO:5737; cytoplasm GO:16020; membrane GO:5794; Golgi apparatus GO:31410; cytoplasmic vesicle GO:43231; intracellular membrane-bounded organelle GO:5783; endoplasmic reticulum GO:5789; endoplasmic reticulum membrane GO:5768; endosome GO:5739; mitochondrion GO:5743; mitochondrial inner membrane GO:5759; mitochondrial matrix
	And 38 more GO terms

Function:	GO:5515; protein binding GO:166; nucleotide binding GO:4672; protein kinase activity GO:4674; protein serine/threonine kinase activity GO:4712; protein serine/threonine/tyrosine kinase activity GO:5524; ATP binding GO:16301; kinase activity GO:16740; transferase activity GO:106310; protein serine kinase activity GO:16787; hydrolase activity GO:5525; GTP binding
	And 23 more GO terms

Show all GO terms