Cell Senescence Entries for MAD2L1

Cell Types
Breast epithelial, Lung fibroblast
Cell Lines
IMR-90, MCF-10A
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lentini et al. (2012) MAD2 depletion triggers premature cellular senescence in human primary fibroblasts by activating a p53 pathway preventing aneuploid cells propagation. J Cell Physiol 227(9)3324-32 (PubMed)

MAD2L1 Gene Information

HGNC symbol
MAD2L1 
Aliases
HSMAD2; MAD2 
Common name
mitotic arrest deficient 2 like 1 
Entrez Id
4085
Description
MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008].

MAD2L1 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:43066; negative regulation of apoptotic process
GO:51301; cell division
GO:132; establishment of mitotic spindle orientation
GO:42177; negative regulation of protein catabolic process
GO:90267; positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:7094; mitotic spindle assembly checkpoint signaling
GO:51444; negative regulation of ubiquitin-protein transferase activity
GO:51660; establishment of centrosome localization
GO:45930; negative regulation of mitotic cell cycle
GO:70; mitotic sister chromatid segregation
And 2 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5856; cytoskeleton
GO:5829; cytosol
GO:5694; chromosome
GO:48471; perinuclear region of cytoplasm
GO:775; chromosome, centromeric region
GO:776; kinetochore
GO:922; spindle pole
GO:72686; mitotic spindle
And 4 more GO terms
Function: GO:5515; protein binding
GO:42803; protein homodimerization activity
GO:42802; identical protein binding
GO:8022; protein C-terminus binding
Show all GO terms

Homologs of MAD2L1 in Model Organisms

Caenorhabditis elegans
mdf-2
Danio rerio
mad2l1
Drosophila melanogaster
mad2
Mus musculus
Mad2l1
Rattus norvegicus
Mad2l1
Saccharomyces cerevisiae
MAD2
Schizosaccharomyces pombe
mad2

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as MAD2
CellAge gene expression
  • This gene is present as MAD2L1

External links

OMIM
601467
Ensembl
ENSG00000164109
Entrez Gene
4085
UniGene
591697
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAD2L1
GeneCards
MAD2L1