Cell Senescence Entries for MAF

Cell Types
Adipose tissue mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Chen et al. (2016) c-Maf regulates pluripotency genes, proliferation/self-renewal, and lineage commitment in ROS-mediated senescence of human mesenchymal stem cells. Oncotarget 6(34)35404-18 (PubMed)

MAF Gene Information

HGNC symbol
MAF 
Aliases
c-MAF 
Common name
MAF bZIP transcription factor 
Entrez Id
4094
Description
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].

MAF Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:6366; transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:2088; lens development in camera-type eye
GO:10628; positive regulation of gene expression
GO:32330; regulation of chondrocyte differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:48468; cell development
GO:48839; inner ear development
GO:70306; lens fiber cell differentiation
And 2 more GO terms
Cellular component: GO:5634; nucleus
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:5737; cytoplasm
Function: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
Show all GO terms

Homologs of MAF in Model Organisms

Danio rerio
uncharacterized_F1Q5
Mus musculus
Maf
Rattus norvegicus
Maf

External links

OMIM
177075
Ensembl
ENSG00000178573
Entrez Gene
4094
UniGene
134859
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAF
GeneCards
MAF