Cell Senescence Entries for MAP2K3

Cell Types
Embryonic kidney, Retinal pigment epithelial
Cell Lines
HEK293T, HTERT-RPE1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lahtela et al. (2013) A high-content cellular senescence screen identifies candidate tumor suppressors, including EPHA3. Cell Cycle 12(4)625-34 (PubMed)

MAP2K3 Gene Information

HGNC symbol
MAP2K3 
Aliases
MAPKK3; MEK3; MKK3; PRKMK3 
Common name
mitogen-activated protein kinase kinase 3 
Entrez Id
5606
Description
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008].

MAP2K3 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:18108; peptidyl-tyrosine phosphorylation
GO:45893; positive regulation of transcription, DNA-templated
GO:7165; signal transduction
GO:35331; negative regulation of hippo signaling
GO:165; MAPK cascade
GO:90398; cellular senescence
GO:35924; cellular response to vascular endothelial growth factor stimulus
GO:45860; positive regulation of protein kinase activity
GO:43536; positive regulation of blood vessel endothelial cell migration
And 12 more GO terms
Cellular component: GO:16020; membrane
GO:5654; nucleoplasm
GO:5829; cytosol
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
GO:19901; protein kinase binding
And 2 more GO terms
Show all GO terms

Homologs of MAP2K3 in Model Organisms

Caenorhabditis elegans
sek-1
Mus musculus
Map2k3
Rattus norvegicus
LOC100911550
Schizosaccharomyces pombe
wis1

In other databases

GenDR gene manipulations
  • A homolog of this gene for Schizosaccharomyces pombe is present as wis1

External links

OMIM
602315
Ensembl
ENSG00000034152
Entrez Gene
5606
UniGene
514012
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAP2K3
GeneCards
MAP2K3