The MAP3K6 gene and its putative association with human ageing

Cell Senescence Entries for MAP3K6

Cell Types: Embryonic kidney, Lung fibroblast
Cell Lines: HEK293T, IMR-90, MRC-5
Cancer Cell?: No
Method: Overexpression
Type of senescence: Unclear
Senescence Effect: Induces
Primary Reference: Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

HGNC symbol: MAP3K6
Aliases: ASK2; MAPKKK6; MEKK6
Common name: mitogen-activated protein kinase kinase kinase 6
Entrez Id: 9064
Description: This gene encodes a serine/threonine protein kinase that forms a component of protein kinase-mediated signal transduction cascades. The encoded kinase participates in the regulation of vascular endothelial growth factor (VEGF) expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

Gene Ontology

Process:

GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:165; MAPK cascade
GO:7165; signal transduction

Cellular component:

Function:	GO:46872; metal ion binding GO:166; nucleotide binding GO:4672; protein kinase activity GO:4674; protein serine/threonine kinase activity GO:4712; protein serine/threonine/tyrosine kinase activity GO:5524; ATP binding GO:16301; kinase activity GO:16740; transferase activity GO:106310; protein serine kinase activity GO:4709; MAP kinase kinase kinase activity GO:287; magnesium ion binding
	And 1 more GO terms

Show all GO terms