Cell Senescence Entries for MAPK1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Deschênes-Simard et al. (2013) Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation. Genes Dev 27(8)900-15 (PubMed)

MAPK1 Gene Information

HGNC symbol
MAPK1 
Aliases
ERK; ERK2; MAPK2; p41mapk; PRKM1; PRKM2 
Common name
mitogen-activated protein kinase 1 
Entrez Id
5594
Description
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014].

MAPK1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:6915; apoptotic process
GO:165; MAPK cascade
GO:7166; cell surface receptor signaling pathway
GO:35556; intracellular signal transduction
GO:10800; positive regulation of peptidyl-threonine phosphorylation
GO:32270; positive regulation of cellular protein metabolic process
GO:32872; regulation of stress-activated MAPK cascade
GO:51493; regulation of cytoskeleton organization
And 52 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5886; plasma membrane
GO:5770; late endosome
GO:5739; mitochondrion
GO:5901; caveola
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5829; cytosol
And 13 more GO terms
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4707; MAP kinase activity
GO:3677; DNA binding
GO:5515; protein binding
And 6 more GO terms
Show all GO terms

Homologs of MAPK1 in Model Organisms

Danio rerio
mapk1
Mus musculus
Mapk1
Rattus norvegicus
Mapk1

In other databases

LongevityMap
  • This gene is present as MAPK1

External links

OMIM
176948
Ensembl
ENSG00000100030
Entrez Gene
5594
UniGene
431850
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAPK1
GeneCards
MAPK1