The MAPK12 gene and its putative association with human ageing

Cell Senescence Entries for MAPK12

Cell Types: Embryonic kidney, Lung fibroblast
Cell Lines: HEK293T, IMR-90, MRC-5
Cancer Cell?: No
Method: Overexpression
Type of senescence: Unclear
Senescence Effect: Induces
Primary Reference: Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

HGNC symbol: MAPK12
Aliases: ERK6; p38gamma; PRKM12; SAPK-3; SAPK3
Common name: mitogen-activated protein kinase 12
Entrez Id: 6300
Description: Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008].

Gene Ontology

Process:	GO:6468; protein phosphorylation GO:7049; cell cycle GO:16310; phosphorylation GO:165; MAPK cascade GO:35556; intracellular signal transduction GO:7165; signal transduction GO:7517; muscle organ development GO:18105; peptidyl-serine phosphorylation GO:51726; regulation of cell cycle GO:45445; myoblast differentiation GO:6975; DNA damage induced protein phosphorylation
	And 4 more GO terms

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5654; nucleoplasm
GO:5829; cytosol

Function:	GO:46872; metal ion binding GO:166; nucleotide binding GO:4672; protein kinase activity GO:4674; protein serine/threonine kinase activity GO:4712; protein serine/threonine/tyrosine kinase activity GO:5524; ATP binding GO:16301; kinase activity GO:16740; transferase activity GO:106310; protein serine kinase activity GO:4707; MAP kinase activity GO:5515; protein binding
	And 2 more GO terms

Show all GO terms