Cell Senescence Entries for MARCHF5

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Park et al. (2010) Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1. J Cell Sci 123(Pt 4)619-26 (PubMed)

MARCHF5 Gene Information

HGNC symbol
MARCHF5 
Aliases
FLJ20445; MARCH-V; MARCH5; MITOL; RNF153 
Common name
membrane associated ring-CH-type finger 5 
Entrez Id
54708
Description
MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM, Mar 2008].

MARCHF5 Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:51865; protein autoubiquitination
GO:209; protein polyubiquitination
GO:90141; positive regulation of mitochondrial fission
GO:70585; protein localization to mitochondrion
GO:90140; regulation of mitochondrial fission
GO:90344; negative regulation of cell aging
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5739; mitochondrion
GO:5741; mitochondrial outer membrane
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:5515; protein binding
GO:61630; ubiquitin protein ligase activity
GO:51020; GTPase binding
Show all GO terms

Homologs of MARCHF5 in Model Organisms

Danio rerio
march5
Drosophila melanogaster
CG9855
Mus musculus
March5
Rattus norvegicus
March5

External links

OMIM
610637
Ensembl
ENSG00000198060
Entrez Gene
54708
UniGene
573490
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MARCHF5
GeneCards
MARCHF5