Cell Senescence Entries for MARCKS

Cell Types
Glioblastoma
Cell Lines
U251, U87
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Jarboe et al. (2012) MARCKS regulates growth and radiation sensitivity and is a novel prognostic factor for glioma. Clin Cancer Res 18(11)3030-41 (PubMed)

MARCKS Gene Information

HGNC symbol
MARCKS 
Aliases
80K-L; MACS; PKCSL 
Common name
myristoylated alanine rich protein kinase C substrate 
Entrez Id
4082
Description
The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008].

MARCKS Ontologies

Gene Ontology
Process: GO:7015; actin filament organization
GO:7417; central nervous system development
GO:51017; actin filament bundle assembly
GO:51764; actin crosslink formation
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5886; plasma membrane
GO:70062; extracellular exosome
GO:15629; actin cytoskeleton
GO:32432; actin filament bundle
GO:5813; centrosome
GO:5938; cell cortex
GO:42585; germinal vesicle
And 1 more GO terms
Function: GO:3779; actin binding
GO:5516; calmodulin binding
GO:51015; actin filament binding
GO:5080; protein kinase C binding
GO:42802; identical protein binding
Show all GO terms

Homologs of MARCKS in Model Organisms

Danio rerio
marcksa
Mus musculus
Marcks
Rattus norvegicus
Marcks

External links

OMIM
177061
Ensembl
ENSG00000277443
Entrez Gene
4082
UniGene
712658
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MARCKS
GeneCards
MARCKS