Cell Senescence Entries for MAST1

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

MAST1 Gene Information

HGNC symbol
MAST1 
Aliases
KIAA0973; SAST 
Common name
microtubule associated serine/threonine kinase 1 
Entrez Id
22983
Description
This gene is a member of the microtubule-associated serine/threonine kinase (MAST) family. The protein encoded by this gene has an N-terminal serine/threonine kinase domain followed by a postsynaptic density protein-95/discs large/zona occludens-1 (PDZ) domain. In mouse and rat, the orthologous protein associates with the cytoskeleton and can bind both beta-2-syntrophin and neuronal nitric oxide synthase (nNOS) through its PDZ domain. In mouse and rat, this protein also co-localizes with dystrophin- and utrophin-associated protein complexes (DAPC/UAPC) in the vascular endothelium of the central nervous system. [provided by RefSeq, May 2017].

MAST1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:35556; intracellular signal transduction
GO:7010; cytoskeleton organization
GO:16310; phosphorylation
GO:18105; peptidyl-serine phosphorylation
GO:7420; brain development
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:42995; cell projection
GO:30425; dendrite
GO:43005; neuron projection
GO:30424; axon
GO:43025; neuronal cell body
Function: GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:287; magnesium ion binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
And 2 more GO terms
Show all GO terms

Homologs of MAST1 in Model Organisms

Danio rerio
LOC796144
Mus musculus
Mast1
Rattus norvegicus
Mast1

External links

OMIM
612256
Ensembl
ENSG00000105613
Entrez Gene
22983
UniGene
227489
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MAST1
GeneCards
MAST1