Cell Senescence Entries for MATK

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

MATK Gene Information

HGNC symbol
MATK 
Aliases
CHK; CTK; DKFZp434N1212; HHYLTK; HYL; HYLTK; Lsk; MGC1708; MGC2101 
Common name
megakaryocyte-associated tyrosine kinase 
Entrez Id
4145
Description
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

MATK Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:18108; peptidyl-tyrosine phosphorylation
GO:8284; positive regulation of cell population proliferation
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4713; protein tyrosine kinase activity
GO:5515; protein binding
GO:4715; non-membrane spanning protein tyrosine kinase activity
Show all GO terms

Homologs of MATK in Model Organisms

Caenorhabditis elegans
csk-1
Danio rerio
matk
Mus musculus
Matk
Rattus norvegicus
Matk

External links

OMIM
600038
Ensembl
ENSG00000007264
Entrez Gene
4145
UniGene
631845
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MATK
GeneCards
MATK