Cell Senescence Entries for MCM7

Cell Types
Mammary fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Avelar et al. (2021) A multidimensional systems biology analysis of cellular senescence in aging and disease. Genome Biol 21(1)91 (PubMed)

MCM7 Gene Information

HGNC symbol
MCM7 
Aliases
CDC47; MCM2; PPP1R104 
Common name
minichromosome maintenance complex component 7 
Entrez Id
4176
Description
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].

MCM7 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:6974; cellular response to DNA damage stimulus
GO:6260; DNA replication
GO:6270; DNA replication initiation
GO:6268; DNA unwinding involved in DNA replication
GO:8283; cell population proliferation
GO:9410; response to xenobiotic stimulus
GO:32508; DNA duplex unwinding
GO:71310; cellular response to organic substance
GO:71364; cellular response to epidermal growth factor stimulus
GO:71466; cellular response to xenobiotic stimulus
And 5 more GO terms
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:16020; membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5694; chromosome
GO:42555; MCM complex
GO:71162; CMG complex
GO:785; chromatin
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:3677; DNA binding
GO:16787; hydrolase activity
GO:5515; protein binding
GO:4386; helicase activity
GO:16887; ATP hydrolysis activity
GO:3678; DNA helicase activity
GO:3697; single-stranded DNA binding
GO:17116; single-stranded DNA helicase activity
Show all GO terms

Homologs of MCM7 in Model Organisms

Caenorhabditis elegans
mcm-7
Danio rerio
mcm7
Drosophila melanogaster
Mcm7
Mus musculus
Mcm7
Rattus norvegicus
Mcm7
Saccharomyces cerevisiae
MCM7
Schizosaccharomyces pombe
mcm7

In other databases

CellAge gene expression
  • This gene is present as MCM7

External links

OMIM
600592
Ensembl
ENSG00000166508
Entrez Gene
4176
UniGene
438720
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MCM7
GeneCards
MCM7