Cell Senescence Entries for MDH1

Cell Types
Dermal fibroblast, Lung fibroblast
Cell Lines
IMR-90, Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2013) Cytosolic malate dehydrogenase regulates senescence in human fibroblasts. Biogerontology 13(5)525-36 (PubMed)

MDH1 Gene Information

HGNC symbol
MDH1 
Aliases
 
Common name
malate dehydrogenase 1 
Entrez Id
4190
Description
This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. [provided by RefSeq, Feb 2016].

MDH1 Ontologies

Gene Ontology
Process: GO:6099; tricarboxylic acid cycle
GO:6108; malate metabolic process
GO:19752; carboxylic acid metabolic process
GO:6734; NADH metabolic process
GO:6107; oxaloacetate metabolic process
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5615; extracellular space
GO:5813; centrosome
GO:70062; extracellular exosome
Function: GO:16491; oxidoreductase activity
GO:3824; catalytic activity
GO:16616; oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:5515; protein binding
GO:16615; malate dehydrogenase activity
GO:30060; L-malate dehydrogenase activity
GO:4470; malic enzyme activity
GO:47860; diiodophenylpyruvate reductase activity
Show all GO terms

Homologs of MDH1 in Model Organisms

Danio rerio
mdh1a
Drosophila melanogaster
Mdh1
Mus musculus
Mdh1
Rattus norvegicus
Mdh1

External links

OMIM
154200
Ensembl
ENSG00000014641
Entrez Gene
4190
UniGene
526521
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MDH1
GeneCards
MDH1