Cell Senescence Entries for MDM2

Cell Types
Glioblastoma
Cell Lines
U-373MG
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kovatcheva et al. (2016) MDM2 turnover and expression of ATRX determine the choice between quiescence and senescence in response to CDK4 inhibition. Oncotarget 6(10)8226-43 (PubMed)

MDM2 Gene Information

HGNC symbol
MDM2 
Aliases
HDM2; MGC5370 
Common name
MDM2 proto-oncogene 
Entrez Id
4193
Description
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013].

MDM2 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:16567; protein ubiquitination
GO:6915; apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:51865; protein autoubiquitination
GO:6511; ubiquitin-dependent protein catabolic process
GO:51726; regulation of cell cycle
GO:6357; regulation of transcription by RNA polymerase II
GO:42176; regulation of protein catabolic process
GO:16925; protein sumoylation
And 36 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:32991; protein-containing complex
GO:5730; nucleolus
GO:5654; nucleoplasm
GO:5886; plasma membrane
GO:5829; cytosol
GO:17053; transcription repressor complex
GO:30666; endocytic vesicle membrane
GO:16604; nuclear body
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:8270; zinc ion binding
GO:31625; ubiquitin protein ligase binding
GO:16874; ligase activity
GO:61630; ubiquitin protein ligase activity
GO:4842; ubiquitin-protein transferase activity
GO:43130; ubiquitin binding
GO:19899; enzyme binding
GO:42802; identical protein binding
And 9 more GO terms
Show all GO terms

Homologs of MDM2 in Model Organisms

Danio rerio
mdm2
Mus musculus
Mdm2
Rattus norvegicus
Mdm2

In other databases

GenAge human genes
  • This gene is present as MDM2
LongevityMap
  • This gene is present as MDM2
CellAge gene expression
  • This gene is present as MDM2

External links

OMIM
164785
Ensembl
ENSG00000135679
Entrez Gene
4193
UniGene
733536
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MDM2
GeneCards
MDM2