Cell Senescence Entries for ME1

Cell Types
Squamous carcinoma
Cell Lines
WSU-HN30, WSU-HN31
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Woo et al. (2018) Down-regulation of malic enzyme 1 and 2: Sensitizing head and neck squamous cell carcinoma cells to therapy-induced senescence. Head Neck 38 Suppl 1(2)E934-40 (PubMed)

ME1 Gene Information

HGNC symbol
ME1 
Aliases
 
Common name
malic enzyme 1 
Entrez Id
4199
Description
This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. [provided by RefSeq, Jul 2008].

ME1 Ontologies

Gene Ontology
Process: GO:9165; nucleotide biosynthetic process
GO:22900; electron transport chain
GO:5975; carbohydrate metabolic process
GO:9725; response to hormone
GO:6108; malate metabolic process
GO:6090; pyruvate metabolic process
GO:1902031; regulation of NADP metabolic process
GO:9743; response to carbohydrate
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5739; mitochondrion
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:51287; NAD binding
GO:30145; manganese ion binding
GO:42802; identical protein binding
GO:4470; malic enzyme activity
GO:4471; malate dehydrogenase (decarboxylating) (NAD+) activity
GO:9055; electron transfer activity
GO:50661; NADP binding
GO:4473; malate dehydrogenase (decarboxylating) (NADP+) activity
GO:8948; oxaloacetate decarboxylase activity
And 2 more GO terms
Show all GO terms

Homologs of ME1 in Model Organisms

Drosophila melanogaster
Men
Mus musculus
Me1
Rattus norvegicus
Me1
Schizosaccharomyces pombe
mae2

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Men
GenDR gene manipulations
  • A homolog of this gene for Drosophila melanogaster is present as Men

External links

OMIM
154250
Ensembl
ENSG00000065833
Entrez Gene
4199
UniGene
21160
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ME1
GeneCards
ME1