Cell Senescence Entries for ME2
- Cell Types
- Squamous carcinoma
- Cell Lines
- WSU-HN30, WSU-HN31
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Stress-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Woo et al. (2018) Down-regulation of malic enzyme 1 and 2: Sensitizing head and neck squamous cell carcinoma cells to therapy-induced senescence. Head Neck 38 Suppl 1(2)E934-40 (PubMed)
ME2 Gene Information
- HGNC symbol
- ME2
- Aliases
- Common name
- malic enzyme 2
- Entrez Id
- 4200
- Description
- This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009].
ME2 Ontologies
- Gene Ontology
-
Process: GO:8152; metabolic process
GO:22900; electron transport chain
GO:6108; malate metabolic process
GO:6090; pyruvate metabolic process
GO:1902031; regulation of NADP metabolic process
Cellular component: GO:43231; intracellular membrane-bounded organelle
GO:5739; mitochondrion
GO:5759; mitochondrial matrix
Show all GO termsFunction: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:51287; NAD binding
GO:3824; catalytic activity
GO:4470; malic enzyme activity
GO:4471; malate dehydrogenase (decarboxylating) (NAD+) activity
GO:9055; electron transfer activity
GO:4473; malate dehydrogenase (decarboxylating) (NADP+) activity
GO:8948; oxaloacetate decarboxylase activity
Homologs of ME2 in Model Organisms
- Caenorhabditis elegans
- men-1
- Danio rerio
- me2
- Mus musculus
- Me2
- Rattus norvegicus
- Me2
- Saccharomyces cerevisiae
- MAE1
External links
- OMIM
- 154270
- Ensembl
- ENSG00000082212
- Entrez Gene
- 4200
- UniGene
- 233119
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ME2
- GeneCards
- ME2