Cell Senescence Entries for MECP2

Cell Types
Mesenchymal stem
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Squillaro et al. (2010) Partial silencing of methyl cytosine protein binding 2 (MECP2) in mesenchymal stem cells induces senescence with an increase in damaged DNA. FASEB J 24(5)1593-603 (PubMed)

MECP2 Gene Information

HGNC symbol
MECP2 
Aliases
MRX16; MRX79; RTT 
Common name
methyl-CpG binding protein 2 
Entrez Id
4204
Description
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of cognitive disability in females. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015].

MECP2 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:10629; negative regulation of gene expression
GO:16525; negative regulation of angiogenesis
GO:8284; positive regulation of cell population proliferation
GO:1905643; positive regulation of DNA methylation
GO:43537; negative regulation of blood vessel endothelial cell migration
GO:10971; positive regulation of G2/M transition of mitotic cell cycle
GO:6349; regulation of gene expression by genetic imprinting
GO:7052; mitotic spindle organization
GO:90063; positive regulation of microtubule nucleation
And 53 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5615; extracellular space
GO:45202; synapse
GO:98794; postsynapse
GO:792; heterochromatin
GO:5813; centrosome
GO:5737; cytoplasm
GO:5829; cytosol
Function: GO:3723; RNA binding
GO:3677; DNA binding
GO:5515; protein binding
GO:3682; chromatin binding
GO:10385; double-stranded methylated DNA binding
GO:19904; protein domain specific binding
GO:47485; protein N-terminus binding
GO:3714; transcription corepressor activity
GO:8327; methyl-CpG binding
GO:3700; DNA-binding transcription factor activity
GO:3729; mRNA binding
And 3 more GO terms
Show all GO terms

Homologs of MECP2 in Model Organisms

Danio rerio
mecp2
Mus musculus
Mecp2
Rattus norvegicus
Mecp2

External links

OMIM
300005
Ensembl
ENSG00000169057
Entrez Gene
4204
UniGene
702514
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MECP2
GeneCards
MECP2