Cell Senescence Entries for MINK1

Cell Types
Airway epithelial, Foreskin fibroblast, Ovarian cancer
Cell Lines
HOSE 6-3, HS68, Primary cell
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Nicke et al. (2006) Involvement of MINK, a Ste20 family kinase, in Ras oncogene-induced growth arrest in human ovarian surface epithelial cells. Mol Cell 20(5)673-85 (PubMed)

MINK1 Gene Information

HGNC symbol
MINK1 
Aliases
B55; MAP4K6; MINK; YSK2; ZC3 
Common name
misshapen like kinase 1 
Entrez Id
50488
Description
This gene encodes a serine/threonine kinase belonging to the germinal center kinase (GCK) family. The protein is structurally similar to the kinases that are related to NIK and may belong to a distinct subfamily of NIK-related kinases within the GCK family. Studies of the mouse homolog indicate an up-regulation of expression in the course of postnatal mouse cerebral development and activation of the cJun N-terminal kinase (JNK) and the p38 pathways. [provided by RefSeq, Mar 2016].

MINK1 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:46777; protein autophosphorylation
GO:35556; intracellular signal transduction
GO:7268; chemical synaptic transmission
GO:30334; regulation of cell migration
GO:48812; neuron projection morphogenesis
GO:7420; brain development
GO:165; MAPK cascade
GO:46330; positive regulation of JNK cascade
GO:31532; actin cytoskeleton reorganization
And 8 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5794; Golgi apparatus
GO:30054; cell junction
GO:42995; cell projection
GO:30425; dendrite
GO:45202; synapse
GO:30424; axon
GO:14069; postsynaptic density
GO:5829; cytosol
GO:70062; extracellular exosome
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
Show all GO terms

Homologs of MINK1 in Model Organisms

Danio rerio
mink1
Drosophila melanogaster
msn
Mus musculus
Mink1
Rattus norvegicus
Mink1

External links

OMIM
609426
Ensembl
ENSG00000141503
Entrez Gene
50488
UniGene
443417
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MINK1
GeneCards
MINK1