Cell Senescence Entries for MME

Cell Types
Mammary epithelial
Cell Lines
MCF-10A
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced, Stress-induced
Senescence Effect
Induces
Primary Reference
Liu et al. (2019) Membrane metallo-endopeptidase mediates cellular senescence induced by oncogenic PIK3CAH1047R accompanied with pro-tumorigenic secretome. Int J Cancer 145(3)817-829 (PubMed)

MME Gene Information

HGNC symbol
MME 
Aliases
CALLA; CD10; NEP 
Common name
membrane metalloendopeptidase 
Entrez Id
4311
Description
The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017].

MME Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:1822; kidney development
GO:71345; cellular response to cytokine stimulus
GO:19233; sensory perception of pain
GO:71493; cellular response to UV-B
GO:150094; amyloid-beta clearance by cellular catabolic process
GO:16485; protein processing
GO:7611; learning or memory
GO:97242; amyloid-beta clearance
GO:71492; cellular response to UV-A
GO:50769; positive regulation of neurogenesis
And 10 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5925; focal adhesion
GO:30425; dendrite
GO:45202; synapse
GO:30424; axon
GO:8021; synaptic vesicle
GO:5887; integral component of plasma membrane
GO:70062; extracellular exosome
And 11 more GO terms
Function: GO:46872; metal ion binding
GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:8270; zinc ion binding
GO:5515; protein binding
GO:4222; metalloendopeptidase activity
GO:8237; metallopeptidase activity
GO:4175; endopeptidase activity
GO:42803; protein homodimerization activity
GO:42277; peptide binding
GO:1786; phosphatidylserine binding
And 4 more GO terms
Show all GO terms

Homologs of MME in Model Organisms

Drosophila melanogaster
Nep1
Mus musculus
Mme
Rattus norvegicus
Mme

External links

OMIM
120520
Ensembl
ENSG00000196549
Entrez Gene
4311
UniGene
307734
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MME
GeneCards
MME