Cell Senescence Entries for MMP7

Cell Types
Mammary epithelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Bertram et al. (2008) MMP-7 is involved in the aging of primary human mammary epithelial cells (HMEC). Exp Gerontol 43(3)209-17 (PubMed)

MMP7 Gene Information

HGNC symbol
MMP7 
Aliases
MPSL1; PUMP-1 
Common name
matrix metallopeptidase 7 
Entrez Id
4316
Description
This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal hemopexin domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes on chromosome 11. This gene exhibits elevated expression levels in multiple human cancers. [provided by RefSeq, Jan 2016].

MMP7 Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:30574; collagen catabolic process
GO:30198; extracellular matrix organization
GO:30335; positive regulation of cell migration
GO:22617; extracellular matrix disassembly
GO:6509; membrane protein ectodomain proteolysis
GO:31293; membrane protein intracellular domain proteolysis
Cellular component: GO:5576; extracellular region
GO:31012; extracellular matrix
GO:5615; extracellular space
GO:70062; extracellular exosome
Function: GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:4222; metalloendopeptidase activity
GO:8237; metallopeptidase activity
GO:4175; endopeptidase activity
GO:4252; serine-type endopeptidase activity
Show all GO terms

Homologs of MMP7 in Model Organisms

Caenorhabditis elegans
CELE_T21D11.1
Mus musculus
Mmp7
Rattus norvegicus
Mmp7

External links

OMIM
178990
Ensembl
ENSG00000137673
Entrez Gene
4316
UniGene
2256
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MMP7
GeneCards
MMP7