Cell Senescence Entries for MNX1
- Cell Types
- Fibrosarcoma
- Cell Lines
- HT1080
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Ingenhag et al. (2020) The homeobox transcription factor HB9 induces senescence and blocks differentiation in hematopoietic stem and progenitor cells. Haematologica 104(1)35-46 (PubMed)
MNX1 Gene Information
- HGNC symbol
- MNX1
- Aliases
- HB9; HLXB9; HOXHB9; SCRA1
- Common name
- motor neuron and pancreas homeobox 1
- Entrez Id
- 3110
- Description
- This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].
MNX1 Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:7417; central nervous system development
GO:21520; spinal cord motor neuron cell fate specification
GO:48812; neuron projection morphogenesis
GO:31018; endocrine pancreas development
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:5829; cytosol
GO:785; chromatin
Show all GO termsFunction: GO:3677; DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:1990837; sequence-specific double-stranded DNA binding
Homologs of MNX1 in Model Organisms
External links
- OMIM
- 142994
- Ensembl
- ENSG00000130675
- Entrez Gene
- 3110
- UniGene
- 37035
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- MNX1
- GeneCards
- MNX1