Cell Senescence Entries for MORC3

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Takahashi et al. (2007) Dynamic regulation of p53 subnuclear localization and senescence by MORC3. Mol Biol Cell 18(5)1701-9 (PubMed)

MORC3 Gene Information

HGNC symbol
MORC3 
Aliases
KIAA0136; NXP2; ZCW5; ZCWCC3 
Common name
MORC family CW-type zinc finger 3 
Entrez Id
23515
Description
This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016].

MORC3 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:18105; peptidyl-serine phosphorylation
GO:51457; maintenance of protein location in nucleus
GO:50821; protein stabilization
GO:7569; cell aging
GO:48147; negative regulation of fibroblast proliferation
GO:9791; post-embryonic development
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:16605; PML body
GO:16363; nuclear matrix
Function: GO:3723; RNA binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:5515; protein binding
GO:16887; ATP hydrolysis activity
GO:35064; methylated histone binding
Show all GO terms

Homologs of MORC3 in Model Organisms

Danio rerio
morc3a
Mus musculus
Morc3
Rattus norvegicus
Morc3

External links

OMIM
610078
Ensembl
ENSG00000159256
Entrez Gene
23515
UniGene
421150
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MORC3
GeneCards
MORC3