Cell Senescence Entries for MOS

Cell Types
Lung fibroblast
Cell Lines
MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Bartkova et al. (2007) Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444(7119)633-7 (PubMed)

MOS Gene Information

HGNC symbol
MOS 
Aliases
 
Common name
MOS proto-oncogene, serine/threonine kinase 
Entrez Id
4342
Description
MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009].

MOS Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6325; chromatin organization
GO:165; MAPK cascade
GO:46777; protein autophosphorylation
GO:7165; signal transduction
GO:43410; positive regulation of MAPK cascade
GO:212; meiotic spindle organization
GO:40020; regulation of meiotic nuclear division
GO:51296; establishment of meiotic spindle orientation
GO:1902103; negative regulation of metaphase/anaphase transition of meiotic cell cycle
And 1 more GO terms
Cellular component: GO:5829; cytosol
GO:5737; cytoplasm
Function: GO:166; nucleotide binding
GO:4672; protein kinase activity
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:5515; protein binding
GO:4709; MAP kinase kinase kinase activity
Show all GO terms

Homologs of MOS in Model Organisms

Danio rerio
mos
Drosophila melanogaster
mos
Mus musculus
Mos
Rattus norvegicus
Mos

External links

OMIM
190060
Ensembl
ENSG00000172680
Entrez Gene
4342
UniGene
533432
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MOS
GeneCards
MOS