Cell Senescence Entries for MST1

Cell Types
Skeletal myoblast
Cell Lines
HSMM
Cancer Cell?
Yes
Method
Mutation, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Crose et al. (2014) Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. J Clin Invest 124(1)285-96 (PubMed)

MST1 Gene Information

HGNC symbol
MST1 
Aliases
D3F15S2; DNF15S2; HGFL; MSP; NF15S2 
Common name
macrophage stimulating 1 
Entrez Id
4485
Description
The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010].

MST1 Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:7283; spermatogenesis
GO:7566; embryo implantation
GO:10628; positive regulation of gene expression
GO:10758; regulation of macrophage chemotaxis
GO:30317; flagellated sperm motility
GO:30879; mammary gland development
GO:33601; positive regulation of mammary gland epithelial cell proliferation
GO:46425; regulation of receptor signaling pathway via JAK-STAT
GO:60763; mammary duct terminal end bud growth
GO:71456; cellular response to hypoxia
And 2 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5773; vacuole
Function: GO:4252; serine-type endopeptidase activity
GO:30971; receptor tyrosine kinase binding
GO:19899; enzyme binding
Show all GO terms

Homologs of MST1 in Model Organisms

Mus musculus
Mst1
Rattus norvegicus
Mst1

External links

OMIM
142408
Ensembl
ENSG00000173531
Entrez Gene
4485
UniGene
512587
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MST1
GeneCards
MST1