Cell Senescence Entries for MTHFD2

Cell Types
Mammary fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Avelar et al. (2021) A multidimensional systems biology analysis of cellular senescence in aging and disease. Genome Biol 21(1)91 (PubMed)

MTHFD2 Gene Information

HGNC symbol
MTHFD2 
Aliases
 
Common name
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 
Entrez Id
10797
Description
This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7. [provided by RefSeq, Mar 2009].

MTHFD2 Ontologies

Gene Ontology
Process: GO:6730; one-carbon metabolic process
GO:6760; folic acid-containing compound metabolic process
GO:8152; metabolic process
GO:46653; tetrahydrofolate metabolic process
GO:35999; tetrahydrofolate interconversion
GO:46655; folic acid metabolic process
Cellular component: GO:5739; mitochondrion
GO:5615; extracellular space
GO:5759; mitochondrial matrix
Function: GO:16787; hydrolase activity
GO:3824; catalytic activity
GO:4488; methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:4477; methenyltetrahydrofolate cyclohydrolase activity
GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:287; magnesium ion binding
GO:42301; phosphate ion binding
GO:4487; methylenetetrahydrofolate dehydrogenase (NAD+) activity
Show all GO terms

Homologs of MTHFD2 in Model Organisms

Danio rerio
mthfd2
Mus musculus
Mthfd2
Rattus norvegicus
Mthfd2
Saccharomyces cerevisiae
MTD1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as MTD1
CellAge gene expression
  • This gene is present as MTHFD2

External links

OMIM
604887
Ensembl
ENSG00000065911
Entrez Gene
10797
UniGene
469030
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MTHFD2
GeneCards
MTHFD2