Cell Senescence Entries for MUC4

Cell Types
Cutaneous squamous cell carcinoma
Cell Lines
SCC1, UM-SCC-10B
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Macha et al. (2015) MUC4 regulates cellular senescence in head and neck squamous cell carcinoma through p16/Rb pathway. Oncogene 34(13)1698-708 (PubMed)

MUC4 Gene Information

HGNC symbol
MUC4 
Aliases
 
Common name
mucin 4, cell surface associated 
Entrez Id
4585
Description
The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats. [provided by RefSeq, Jul 2008].

MUC4 Ontologies

Gene Ontology
Process: GO:7160; cell-matrix adhesion
GO:7155; cell adhesion
GO:30277; maintenance of gastrointestinal epithelium
GO:10469; regulation of signaling receptor activity
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5576; extracellular region
GO:5615; extracellular space
GO:31982; vesicle
GO:31012; extracellular matrix
GO:70062; extracellular exosome
GO:5887; integral component of plasma membrane
GO:5796; Golgi lumen
Function: GO:30197; extracellular matrix constituent, lubricant activity
GO:5176; ErbB-2 class receptor binding
Show all GO terms

Homologs of MUC4 in Model Organisms

Danio rerio
uncharacterized_E7FE
Mus musculus
Muc4
Rattus norvegicus
Muc4

External links

OMIM
158372
Ensembl
ENSG00000145113
Entrez Gene
4585
UniGene
369646
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MUC4
GeneCards
MUC4