Cell Senescence Entries for MUS81

Cell Types
Osteosarcoma, Ovarian cancer
Cell Lines
A2780, U2OS
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Xing et al. (2016) Acute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response. Oncotarget 6(35)37638-46 (PubMed)
Cell Types
Osteosarcoma, Ovarian cancer
Cell Lines
A2780, U2OS
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Xie et al. (2017) MUS81 is associated with cell proliferation and cisplatin sensitivity in serous ovarian cancer. Biochem Biophys Res Commun 476(4)493-500 (PubMed)

MUS81 Gene Information

HGNC symbol
MUS81 
Aliases
FLJ44872; SLX3 
Common name
MUS81 structure-specific endonuclease subunit 
Entrez Id
80198
Description
This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks. [provided by RefSeq, Jun 2017].

MUS81 Ontologies

Gene Ontology
Process: GO:6302; double-strand break repair
GO:737; DNA catabolic process, endonucleolytic
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6310; DNA recombination
GO:6259; DNA metabolic process
GO:712; resolution of meiotic recombination intermediates
GO:31297; replication fork processing
GO:31573; mitotic intra-S DNA damage checkpoint signaling
GO:727; double-strand break repair via break-induced replication
GO:72429; response to intra-S DNA damage checkpoint signaling
And 2 more GO terms
Cellular component: GO:5634; nucleus
GO:5730; nucleolus
GO:5654; nucleoplasm
GO:1905347; endodeoxyribonuclease complex
GO:48476; Holliday junction resolvase complex
GO:43596; nuclear replication fork
Function: GO:8821; crossover junction endodeoxyribonuclease activity
GO:16787; hydrolase activity
GO:3677; DNA binding
GO:4518; nuclease activity
GO:5515; protein binding
GO:46872; metal ion binding
GO:4519; endonuclease activity
GO:48257; 3'-flap endonuclease activity
Show all GO terms

Homologs of MUS81 in Model Organisms

Danio rerio
mus81
Drosophila melanogaster
mus81
Mus musculus
Mus81
Rattus norvegicus
Mus81
Saccharomyces cerevisiae
MUS81
Schizosaccharomyces pombe
mus81

External links

OMIM
606591
Ensembl
ENSG00000172732
Entrez Gene
80198
UniGene
288798
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MUS81
GeneCards
MUS81