Cell Senescence Entries for MVK

Cell Types
Embryonic kidney, Lung fibroblast
Cell Lines
HEK293T, IMR-90, MRC-5
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Ferrand et al. (2016) Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program. Aging (Albany NY) 7(11)986-1003 (PubMed)

MVK Gene Information

HGNC symbol
MVK 
Aliases
LRBP; MK 
Common name
mevalonate kinase 
Entrez Id
4598
Description
This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

MVK Ontologies

Gene Ontology
Process: GO:16310; phosphorylation
GO:6629; lipid metabolic process
GO:8299; isoprenoid biosynthetic process
GO:6694; steroid biosynthetic process
GO:6695; cholesterol biosynthetic process
GO:8202; steroid metabolic process
GO:8203; cholesterol metabolic process
GO:16126; sterol biosynthetic process
GO:19287; isopentenyl diphosphate biosynthetic process, mevalonate pathway
GO:50728; negative regulation of inflammatory response
Cellular component: GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5829; cytosol
GO:5777; peroxisome
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4496; mevalonate kinase activity
GO:46872; metal ion binding
GO:42802; identical protein binding
GO:16773; phosphotransferase activity, alcohol group as acceptor
GO:5515; protein binding
GO:287; magnesium ion binding
Show all GO terms

Homologs of MVK in Model Organisms

Caenorhabditis elegans
mvk-1
Danio rerio
mvk
Drosophila melanogaster
CG16804
Mus musculus
Mvk
Rattus norvegicus
Mvk
Saccharomyces cerevisiae
ERG12
Schizosaccharomyces pombe
erg12

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as mvk-1

External links

OMIM
251170
Ensembl
ENSG00000110921
Entrez Gene
4598
UniGene
130607
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MVK
GeneCards
MVK