Cell Senescence Entries for MXD4
- Cell Types
- Lung fibroblast
- Cell Lines
- WI-38
- Cancer Cell?
- No
- Method
- Mutation, Overexpression
- Type of senescence
- Replicative
- Senescence Effect
- Induces
- Primary Reference
- Marcotte et al. (2003) hMad4, c-Myc endogenous inhibitor, induces a replicative senescence-like state when overexpressed in human fibroblasts. J Cell Biochem 89(3)576-88 (PubMed)
MXD4 Gene Information
- HGNC symbol
- MXD4
- Aliases
- bHLHc12; MAD4; MST149; MSTP149
- Common name
- MAX dimerization protein 4
- Entrez Id
- 10608
- Description
- This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008].
MXD4 Ontologies
- Gene Ontology
-
Process: GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
Cellular component: GO:5634; nucleus
GO:785; chromatin
GO:5654; nucleoplasm
Show all GO termsFunction: GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
Homologs of MXD4 in Model Organisms
- Danio rerio
- uncharacterized_E7F6
- Mus musculus
- Mxd4
In other databases
- CellAge gene expression
- This gene is present as MXD4
External links
- OMIM
- NA
- Ensembl
- ENSG00000123933
- Entrez Gene
- 10608
- UniGene
- 655020
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- MXD4
- GeneCards
- MXD4