Cell Senescence Entries for MYBBP1A

Cell Types
Squamous carcinoma
Cell Lines
FaDu
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
George et al. (2015) Regulation and function of Myb-binding protein 1A (MYBBP1A) in cellular senescence and pathogenesis of head and neck cancer. Cancer Lett 358(2)191-199 (PubMed)

MYBBP1A Gene Information

HGNC symbol
MYBBP1A 
Aliases
FLJ37886; P160; PAP2; Pol5 
Common name
MYB binding protein 1a 
Entrez Id
10514
Description
This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].

MYBBP1A Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:48511; rhythmic process
GO:32922; circadian regulation of gene expression
GO:42254; ribosome biogenesis
GO:45945; positive regulation of transcription by RNA polymerase III
GO:1903450; regulation of G1 to G0 transition
GO:42149; cellular response to glucose starvation
GO:72332; intrinsic apoptotic signaling pathway by p53 class mediator
GO:1649; osteoblast differentiation
GO:6338; chromatin remodeling
And 6 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:5730; nucleolus
GO:5654; nucleoplasm
GO:110016; B-WICH complex
GO:42564; NLS-dependent protein nuclear import complex
Function: GO:3723; RNA binding
GO:3677; DNA binding
GO:3714; transcription corepressor activity
GO:43565; sequence-specific DNA binding
GO:8134; transcription factor binding
GO:70888; E-box binding
Show all GO terms

Homologs of MYBBP1A in Model Organisms

Danio rerio
mybbp1a
Mus musculus
Mybbp1a
Rattus norvegicus
Mybbp1a
Saccharomyces cerevisiae
POL5
Schizosaccharomyces pombe
pol5

External links

OMIM
604885
Ensembl
ENSG00000132382
Entrez Gene
10514
UniGene
701718
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MYBBP1A
GeneCards
MYBBP1A