Cell Senescence Entries for MYBL2

Cell Types
Cervical cancer, Foreskin fibroblast
Cell Lines
HeLa, Primary cell
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Johung et al. (2007) Human papillomavirus E7 repression in cervical carcinoma cells initiates a transcriptional cascade driven by the retinoblastoma family, resulting in senescence. J Virol 81(5)2102-16 (PubMed)

MYBL2 Gene Information

HGNC symbol
MYBL2 
Aliases
B-MYB; BMYB 
Common name
MYB proto-oncogene like 2 
Entrez Id
4605
Description
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013].

MYBL2 Ontologies

Gene Ontology
Process: GO:45944; positive regulation of transcription by RNA polymerase II
GO:6355; regulation of transcription, DNA-templated
GO:278; mitotic cell cycle
GO:43525; positive regulation of neuron apoptotic process
GO:90307; mitotic spindle assembly
GO:1990830; cellular response to leukemia inhibitory factor
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:31523; Myb complex
Function: GO:3677; DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
Show all GO terms

Homologs of MYBL2 in Model Organisms

Danio rerio
mybl2
Drosophila melanogaster
Myb
Mus musculus
Mybl2
Rattus norvegicus
Mybl2

In other databases

CellAge gene expression
  • This gene is present as MYBL2

External links

OMIM
601415
Ensembl
ENSG00000101057
Entrez Gene
4605
UniGene
179718
1000 Genomes
1000 Genomes
HPRD
GenAtlas
MYBL2
GeneCards
MYBL2