Cell Senescence Entries for NDRG1

Cell Types
Liver cancer
Cell Lines
Hep G2, Hep3B, Huh7, PLC/PRF/5
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Lu et al. (2014) Suppressing N-Myc downstream regulated gene 1 reactivates senescence signaling and inhibits tumor growth in hepatocellular carcinoma. Carcinogenesis 35(4)915-22 (PubMed)

NDRG1 Gene Information

HGNC symbol
NDRG1 
Aliases
CAP43; DRG1; NDR1; RTP; TDD5 
Common name
N-myc downstream regulated 1 
Entrez Id
10397
Description
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012].

NDRG1 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:42127; regulation of cell population proliferation
GO:32287; peripheral nervous system myelin maintenance
GO:45576; mast cell activation
GO:30330; DNA damage response, signal transduction by p53 class mediator
GO:71456; cellular response to hypoxia
GO:10038; response to metal ion
GO:8285; negative regulation of cell population proliferation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5886; plasma membrane
GO:5856; cytoskeleton
GO:5912; adherens junction
GO:15630; microtubule cytoskeleton
GO:5874; microtubule
GO:48471; perinuclear region of cytoplasm
GO:55038; recycling endosome membrane
And 4 more GO terms
Function: GO:5515; protein binding
GO:8017; microtubule binding
GO:45296; cadherin binding
GO:31267; small GTPase binding
GO:43015; gamma-tubulin binding
Show all GO terms

Homologs of NDRG1 in Model Organisms

Danio rerio
ndrg1a
Mus musculus
Ndrg1
Rattus norvegicus
Ndrg1

In other databases

GenAge microarray genes
  • This gene is present as NDRG1
CellAge gene expression
  • This gene is present as NDRG1

External links

OMIM
605262
Ensembl
ENSG00000104419
Entrez Gene
10397
UniGene
618002
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NDRG1
GeneCards
NDRG1