Cell Senescence Entries for NEDD4

Cell Types
Lung fibroblast
Cell Lines
2BS, IMR-90
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Han et al. (2013) Upregulation of SIRT1 by 17β-estradiol depends on ubiquitin-proteasome degradation of PPAR-γ mediated by NEDD4-1. Protein Cell 4(4)310-21 (PubMed)

NEDD4 Gene Information

HGNC symbol
NEDD4 
Aliases
KIAA0093; MGC176705; NEDD4-1; RPF1 
Common name
NEDD4 E3 ubiquitin protein ligase 
Entrez Id
4734
Description
This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin proteasome system of protein degradation. The encoded protein contains an N-terminal calcium and phospholipid binding C2 domain followed by multiple tryptophan-rich WW domains and, a C-terminal HECT ubiquitin ligase catalytic domain. It plays critical role in the regulation of a number of membrane receptors, endocytic machinery components and the tumor suppressor PTEN. [provided by RefSeq, Jul 2016].

NEDD4 Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:7399; nervous system development
GO:209; protein polyubiquitination
GO:70534; protein K63-linked ubiquitination
GO:31623; receptor internalization
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:45732; positive regulation of protein catabolic process
GO:31175; neuron projection development
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:7528; neuromuscular junction development
GO:34765; regulation of ion transmembrane transport
And 22 more GO terms
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5794; Golgi apparatus
GO:5886; plasma membrane
GO:5829; cytosol
GO:70062; extracellular exosome
GO:785; chromatin
GO:48471; perinuclear region of cytoplasm
GO:43197; dendritic spine
GO:5938; cell cortex
GO:32991; protein-containing complex
And 3 more GO terms
Function: GO:4842; ubiquitin-protein transferase activity
GO:5515; protein binding
GO:16740; transferase activity
GO:61630; ubiquitin protein ligase activity
GO:19904; protein domain specific binding
GO:70064; proline-rich region binding
GO:31698; beta-2 adrenergic receptor binding
GO:43130; ubiquitin binding
GO:19899; enzyme binding
GO:50815; phosphoserine residue binding
GO:19871; sodium channel inhibitor activity
And 3 more GO terms
Show all GO terms

Homologs of NEDD4 in Model Organisms

Caenorhabditis elegans
CELE_Y92H12A.2
Drosophila melanogaster
Nedd4
Mus musculus
Nedd4
Rattus norvegicus
Nedd4
Saccharomyces cerevisiae
RSP5
Schizosaccharomyces pombe
pub3

External links

OMIM
602278
Ensembl
ENSG00000069869
Entrez Gene
4734
UniGene
1565
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NEDD4
GeneCards
NEDD4