The NEK9 gene and its putative association with human ageing

Cell Senescence Entries for NEK9

Cell Types: Melanoma
Cell Lines: 1205Lu, WM1366
Cancer Cell?: Yes
Method: Knockdown
Type of senescence: Oncogene-induced
Senescence Effect: Inhibits
Primary Reference: Phadke et al. (2019) Dabrafenib inhibits the growth of BRAF-WT cancers through CDK16 and NEK9 inhibition. Mol Oncol 12(1)74-88 (PubMed)

HGNC symbol: NEK9
Aliases: DKFZp434D0935; MGC16714; Nek8; NERCC; NERCC1
Common name: NIMA related kinase 9
Entrez Id: 91754
Description: This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. The encoded protein is activated in mitosis and, in turn, activates other family members during mitosis. This protein also mediates cellular processes that are essential for interphase progression. [provided by RefSeq, Jul 2016].

Gene Ontology

Process:

GO:6468; protein phosphorylation
GO:7049; cell cycle
GO:16310; phosphorylation
GO:51301; cell division

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:5813; centrosome
GO:5829; cytosol

Function:	GO:46872; metal ion binding GO:166; nucleotide binding GO:4672; protein kinase activity GO:4674; protein serine/threonine kinase activity GO:4712; protein serine/threonine/tyrosine kinase activity GO:5524; ATP binding GO:16301; kinase activity GO:16740; transferase activity GO:106310; protein serine kinase activity GO:5515; protein binding GO:19901; protein kinase binding
	And 1 more GO terms

Show all GO terms