Cell Senescence Entries for NF1

Cell Types
Melanocyte
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Larribere et al. (2016) NF1 loss induces senescence during human melanocyte differentiation in an iPSC-based model. Pigment Cell Melanoma Res 28(4)407-16 (PubMed)

NF1 Gene Information

HGNC symbol
NF1 
Aliases
 
Common name
neurofibromin 1 
Entrez Id
4763
Description
This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene. [provided by RefSeq, Jul 2008].

NF1 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:43087; regulation of GTPase activity
GO:43547; positive regulation of GTPase activity
GO:7265; Ras protein signal transduction
GO:48147; negative regulation of fibroblast proliferation
GO:1937; negative regulation of endothelial cell proliferation
GO:165; MAPK cascade
GO:30336; negative regulation of cell migration
GO:43409; negative regulation of MAPK cascade
GO:1649; osteoblast differentiation
GO:1656; metanephros development
And 67 more GO terms
Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:98793; presynapse
GO:5730; nucleolus
GO:5829; cytosol
GO:5737; cytoplasm
GO:30424; axon
GO:30425; dendrite
GO:16021; integral component of membrane
Function: GO:5096; GTPase activator activity
GO:5515; protein binding
GO:8289; lipid binding
GO:8429; phosphatidylethanolamine binding
GO:31210; phosphatidylcholine binding
Show all GO terms

Homologs of NF1 in Model Organisms

Danio rerio
nf1b
Drosophila melanogaster
Nf1
Mus musculus
Nf1
Rattus norvegicus
Nf1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Nf1

External links

OMIM
613113
Ensembl
ENSG00000196712
Entrez Gene
4763
UniGene
113577
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NF1
GeneCards
NF1