Cell Senescence Entries for NHEJ1

Cell Types
Umbilical cord blood
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Carrillo et al. (2017) Mutations in XLF/NHEJ1/Cernunnos gene results in downregulation of telomerase genes expression and telomere shortening. Hum Mol Genet 26(10)1900-1914 (PubMed)

NHEJ1 Gene Information

HGNC symbol
NHEJ1 
Aliases
Cernunnos; FLJ12610; XLF 
Common name
non-homologous end joining factor 1 
Entrez Id
79840
Description
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. [provided by RefSeq, Jul 2008].

NHEJ1 Ontologies

Gene Ontology
Process: GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6302; double-strand break repair
GO:10212; response to ionizing radiation
GO:30217; T cell differentiation
GO:6303; double-strand break repair via nonhomologous end joining
GO:30183; B cell differentiation
GO:7417; central nervous system development
GO:51103; DNA ligation involved in DNA repair
GO:51351; positive regulation of ligase activity
GO:33152; immunoglobulin V(D)J recombination
And 1 more GO terms
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:1650; fibrillar center
GO:5694; chromosome
GO:35861; site of double-strand break
GO:70419; nonhomologous end joining complex
GO:32807; DNA ligase IV complex
Function: GO:5515; protein binding
GO:3677; DNA binding
GO:70182; DNA polymerase binding
GO:45027; DNA end binding
Show all GO terms

Homologs of NHEJ1 in Model Organisms

Danio rerio
nhej1
Mus musculus
Nhej1
Rattus norvegicus
Nhej1

External links

OMIM
611290
Ensembl
ENSG00000187736
Entrez Gene
79840
UniGene
225988
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NHEJ1
GeneCards
NHEJ1