Cell Senescence Entries for NLRX1

Cell Types
Liver cancer
Cell Lines
HCCLM3
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Hu et al. (2019) NOD-like receptor X1 functions as a tumor suppressor by inhibiting epithelial-mesenchymal transition and inducing aging in hepatocellular carcinoma cells. J Hematol Oncol 11(1)28 (PubMed)

NLRX1 Gene Information

HGNC symbol
NLRX1 
Aliases
CLR11.3; NOD9 
Common name
NLR family member X1 
Entrez Id
79671
Description
The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013].

NLRX1 Ontologies

Gene Ontology
Process: GO:2376; immune system process
GO:45087; innate immune response
GO:35556; intracellular signal transduction
GO:43124; negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:32688; negative regulation of interferon-beta production
GO:32715; negative regulation of interleukin-6 production
GO:39536; negative regulation of RIG-I signaling pathway
GO:45824; negative regulation of innate immune response
GO:50728; negative regulation of inflammatory response
Cellular component: GO:5886; plasma membrane
GO:5739; mitochondrion
GO:30054; cell junction
GO:16020; membrane
GO:5741; mitochondrial outer membrane
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:5515; protein binding
Show all GO terms

Homologs of NLRX1 in Model Organisms

Danio rerio
nlrx1
Mus musculus
Nlrx1
Rattus norvegicus
Nlrx1

External links

OMIM
611947
Ensembl
ENSG00000160703
Entrez Gene
79671
UniGene
524082
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NLRX1
GeneCards
NLRX1