Cell Senescence Entries for NOLC1

Cell Types
Lung fibroblast
Cell Lines
2BS
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Yuan et al. (2017) Enhanced NOLC1 promotes cell senescence and represses hepatocellular carcinoma cell proliferation by disturbing the organization of nucleolus. Aging Cell 16(4)726-737 (PubMed)

NOLC1 Gene Information

HGNC symbol
NOLC1 
Aliases
KIAA0035; NOPP130; NOPP140; P130; Srp40 
Common name
nucleolar and coiled-body phosphoprotein 1 
Entrez Id
9221
Description

NOLC1 Ontologies

Gene Ontology
Process: GO:6417; regulation of translation
GO:6364; rRNA processing
GO:278; mitotic cell cycle
GO:14029; neural crest formation
GO:14032; neural crest cell development
GO:6970; response to osmotic stress
GO:7000; nucleolus organization
GO:8284; positive regulation of cell population proliferation
GO:33979; box H/ACA RNA metabolic process
GO:42306; regulation of protein import into nucleus
GO:45893; positive regulation of transcription, DNA-templated
And 1 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:1650; fibrillar center
GO:5730; nucleolus
GO:5654; nucleoplasm
GO:15030; Cajal body
GO:31428; box C/D RNP complex
GO:31429; box H/ACA snoRNP complex
Function: GO:3723; RNA binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:5525; GTP binding
GO:5515; protein binding
GO:46982; protein heterodimerization activity
GO:30674; protein-macromolecule adaptor activity
GO:1093; TFIIB-class transcription factor binding
GO:8139; nuclear localization sequence binding
GO:19904; protein domain specific binding
GO:34512; box C/D RNA binding
And 4 more GO terms
Show all GO terms

Homologs of NOLC1 in Model Organisms

Caenorhabditis elegans
dao-5
Danio rerio
nolc1
Mus musculus
Nolc1
Rattus norvegicus
Nolc1
Saccharomyces cerevisiae
SRP40

External links

OMIM
602394
Ensembl
ENSG00000166197
Entrez Gene
9221
UniGene
523238
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NOLC1
GeneCards
NOLC1