Cell Senescence Entries for NOTCH1

Cell Types
Esophageal keratinocyte
Cell Lines
EPC1, EPC1-hTERT, EPC2-hTERT
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Kagawa et al. (2015) Cellular senescence checkpoint function determines differential Notch1-dependent oncogenic and tumor-suppressor activities. Oncogene 34(18)2347-59 (PubMed)

NOTCH1 Gene Information

HGNC symbol
NOTCH1 
Aliases
TAN1 
Common name
notch receptor 1 
Entrez Id
4851
Description
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016].

NOTCH1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:7219; Notch signaling pathway
GO:1525; angiogenesis
GO:50793; regulation of developmental process
GO:7275; multicellular organism development
GO:10628; positive regulation of gene expression
GO:45944; positive regulation of transcription by RNA polymerase II
GO:45893; positive regulation of transcription, DNA-templated
GO:122; negative regulation of transcription by RNA polymerase II
GO:6955; immune response
And 167 more GO terms
Cellular component: GO:5634; nucleus
GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:5912; adherens junction
GO:16324; apical plasma membrane
GO:5576; extracellular region
GO:5789; endoplasmic reticulum membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:9986; cell surface
And 10 more GO terms
Function: GO:5509; calcium ion binding
GO:38023; signaling receptor activity
GO:5515; protein binding
GO:46872; metal ion binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:4857; enzyme inhibitor activity
GO:3713; transcription coactivator activity
GO:3682; chromatin binding
GO:4888; transmembrane signaling receptor activity
GO:5112; Notch binding
And 2 more GO terms
Show all GO terms

Homologs of NOTCH1 in Model Organisms

Danio rerio
notch1a
Mus musculus
Notch1
Rattus norvegicus
Notch1

External links

OMIM
190198
Ensembl
ENSG00000148400
Entrez Gene
4851
UniGene
495473
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NOTCH1
GeneCards
NOTCH1