Cell Senescence Entries for NQO1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
2BS, BJ, IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Liu et al. (2016) NQO1 Stabilizes p53 in Response to Oncogene-Induced Senescence. Int J Biol Sci 11(7)762-71 (PubMed)

NQO1 Gene Information

HGNC symbol
NQO1 
Aliases
DHQU; DIA4; DTD; NMOR1; QR1 
Common name
NAD(P)H quinone dehydrogenase 1 
Entrez Id
1728
Description
This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

NQO1 Ontologies

Gene Ontology
Process: GO:19430; removal of superoxide radicals
GO:34599; cellular response to oxidative stress
GO:6979; response to oxidative stress
GO:45454; cell redox homeostasis
GO:6805; xenobiotic metabolic process
GO:6809; nitric oxide biosynthetic process
GO:6743; ubiquinone metabolic process
GO:7271; synaptic transmission, cholinergic
GO:9636; response to toxic substance
GO:42360; vitamin E metabolic process
GO:42373; vitamin K metabolic process
And 29 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:45202; synapse
GO:30425; dendrite
GO:43025; neuronal cell body
Function: GO:3723; RNA binding
GO:16491; oxidoreductase activity
GO:5515; protein binding
GO:42802; identical protein binding
GO:4128; cytochrome-b5 reductase activity, acting on NAD(P)H
GO:3955; NAD(P)H dehydrogenase (quinone) activity
GO:8753; NADPH dehydrogenase (quinone) activity
GO:50136; NADH dehydrogenase (quinone) activity
GO:4784; superoxide dismutase activity
Show all GO terms

Homologs of NQO1 in Model Organisms

Danio rerio
nqo1
Mus musculus
Nqo1
Rattus norvegicus
Nqo1

In other databases

LongevityMap
  • This gene is present as NQO1

External links

OMIM
125860
Ensembl
ENSG00000181019
Entrez Gene
1728
UniGene
406515
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NQO1
GeneCards
NQO1