Cell Senescence Entries for NSUN2

Cell Types
Fibroblast
Cell Lines
IDH4
Cancer Cell?
No
Method
Knockdown, Overexpression
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Tang et al. (2016) NSun2 delays replicative senescence by repressing p27 (KIP1) translation and elevating CDK1 translation. Aging (Albany NY) 7(12)1143-58 (PubMed)

NSUN2 Gene Information

HGNC symbol
NSUN2 
Aliases
FLJ20303; Misu; MRT5; TRM4 
Common name
NOP2/Sun RNA methyltransferase 2 
Entrez Id
54888
Description
This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Mar 2011].

NSUN2 Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:1510; RNA methylation
GO:8033; tRNA processing
GO:32259; methylation
GO:51301; cell division
GO:30154; cell differentiation
GO:7283; spermatogenesis
GO:80009; mRNA methylation
GO:30488; tRNA methylation
GO:6400; tRNA modification
GO:36416; tRNA stabilization
And 7 more GO terms
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5576; extracellular region
GO:5856; cytoskeleton
GO:5730; nucleolus
GO:5819; spindle
GO:5654; nucleoplasm
GO:70062; extracellular exosome
GO:33391; chromatoid body
Function: GO:3723; RNA binding
GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:49; tRNA binding
GO:16428; tRNA (cytosine-5-)-methyltransferase activity
GO:62152; mRNA (cytidine-5-)-methyltransferase activity
Show all GO terms

Homologs of NSUN2 in Model Organisms

Caenorhabditis elegans
CELE_Y48G8AL.5
Danio rerio
nsun2
Drosophila melanogaster
CG6133
Mus musculus
Nsun2
Rattus norvegicus
Nsun2
Saccharomyces cerevisiae
NCL1
Schizosaccharomyces pombe
trm4a

External links

OMIM
610916
Ensembl
ENSG00000037474
Entrez Gene
54888
UniGene
481526
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NSUN2
GeneCards
NSUN2