Cell Senescence Entries for NUTF2

Cell Types
Skin fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Larrieu et al. (2019) Inhibition of the acetyltransferase NAT10 normalizes progeric and aging cells by rebalancing the Transportin-1 nuclear import pathway. Sci Signal 11(537)117-26 (PubMed)

NUTF2 Gene Information

HGNC symbol
NUTF2 
Aliases
NTF2; PP15 
Common name
nuclear transport factor 2 
Entrez Id
10204
Description
This gene encodes a cytosolic factor that facilitates protein transport into the nucleus. The encoded protein is required for nuclear import of the small Ras-like GTPase, Ran which is involved in numerous cellular processes. This protein also interacts with the nuclear pore complex glycoprotein p62. [provided by RefSeq, Apr 2016].

NUTF2 Ontologies

Gene Ontology
Process: GO:51028; mRNA transport
GO:15031; protein transport
GO:6913; nucleocytoplasmic transport
GO:6606; protein import into nucleus
GO:6611; protein export from nucleus
GO:90204; protein localization to nuclear pore
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5829; cytosol
GO:5643; nuclear pore
GO:31965; nuclear membrane
GO:5654; nucleoplasm
GO:5637; nuclear inner membrane
GO:5640; nuclear outer membrane
GO:70062; extracellular exosome
GO:44613; nuclear pore central transport channel
And 1 more GO terms
Function: GO:5515; protein binding
GO:42802; identical protein binding
GO:17056; structural constituent of nuclear pore
GO:31267; small GTPase binding
Show all GO terms

Homologs of NUTF2 in Model Organisms

Caenorhabditis elegans
ran-4
Danio rerio
nutf2
Drosophila melanogaster
Ntf-2
Mus musculus
Nutf2
Rattus norvegicus
Nutf2
Saccharomyces cerevisiae
NTF2
Schizosaccharomyces pombe
ntf2

External links

OMIM
605813
Ensembl
ENSG00000102898
Entrez Gene
10204
UniGene
356630
1000 Genomes
1000 Genomes
HPRD
GenAtlas
NUTF2
GeneCards
NUTF2