Cell Senescence Entries for OGG1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Ramdzan et al. (2014) RAS transformation requires CUX1-dependent repair of oxidative DNA damage. PLoS Biol 12(3)e1001807 (PubMed)

OGG1 Gene Information

HGNC symbol
OGG1 
Aliases
HMMH; HOGG1; MUTM; OGH1 
Common name
8-oxoguanine DNA glycosylase 
Entrez Id
4968
Description
This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008].

OGG1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:8152; metabolic process
GO:6284; base-excision repair
GO:6289; nucleotide-excision repair
GO:6979; response to oxidative stress
GO:33683; nucleotide-excision repair, DNA incision
GO:1901291; negative regulation of double-strand break repair via single-strand annealing
GO:6285; base-excision repair, AP site formation
GO:9314; response to radiation
And 12 more GO terms
Cellular component: GO:5634; nucleus
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:16363; nuclear matrix
GO:5829; cytosol
GO:5759; mitochondrial matrix
GO:32991; protein-containing complex
Function: GO:16787; hydrolase activity
GO:3824; catalytic activity
GO:16829; lyase activity
GO:3684; damaged DNA binding
GO:16798; hydrolase activity, acting on glycosyl bonds
GO:140078; class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:5515; protein binding
GO:8534; oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:34039; 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity
GO:4519; endonuclease activity
GO:32357; oxidized purine DNA binding
And 4 more GO terms
Show all GO terms

Homologs of OGG1 in Model Organisms

Danio rerio
ogg1
Drosophila melanogaster
Ogg1
Mus musculus
Ogg1
Rattus norvegicus
Ogg1
Saccharomyces cerevisiae
OGG1

In other databases

LongevityMap
  • This gene is present as OGG1

External links

OMIM
601982
Ensembl
ENSG00000114026
Entrez Gene
4968
UniGene
380271
1000 Genomes
1000 Genomes
HPRD
GenAtlas
OGG1
GeneCards
OGG1