Cell Senescence Entries for OPA1

Cell Types
Cervical cancer, Hepatoma
Cell Lines
ATCC, CCL-13, HeLa
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2007) Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J Biol Chem 282(31)22977-83 (PubMed)

OPA1 Gene Information

HGNC symbol
OPA1 
Aliases
FLJ12460; KIAA0567; MGM1; NPG; NTG 
Common name
OPA1 mitochondrial dynamin like GTPase 
Entrez Id
4976
Description
The protein encoded by this gene is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. The encoded protein localizes to the inner mitochondrial membrane and helps regulate mitochondrial stability and energy output. This protein also sequesters cytochrome c. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. [provided by RefSeq, Aug 2017].

OPA1 Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:50896; response to stimulus
GO:7005; mitochondrion organization
GO:8053; mitochondrial fusion
GO:7601; visual perception
GO:266; mitochondrial fission
GO:7007; inner mitochondrial membrane organization
GO:97749; membrane tubulation
GO:46039; GTP metabolic process
GO:51259; protein complex oligomerization
And 8 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5741; mitochondrial outer membrane
GO:1904115; axon cytoplasm
GO:30425; dendrite
GO:31966; mitochondrial membrane
GO:5758; mitochondrial intermembrane space
And 4 more GO terms
Function: GO:5515; protein binding
GO:166; nucleotide binding
GO:16787; hydrolase activity
GO:3924; GTPase activity
GO:5525; GTP binding
GO:8289; lipid binding
GO:287; magnesium ion binding
GO:8017; microtubule binding
GO:70300; phosphatidic acid binding
GO:1901612; cardiolipin binding
Show all GO terms

Homologs of OPA1 in Model Organisms

Caenorhabditis elegans
eat-3
Danio rerio
opa1
Drosophila melanogaster
opa1-like
Mus musculus
Opa1
Rattus norvegicus
Opa1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as eat-3

External links

OMIM
605290
Ensembl
ENSG00000198836
Entrez Gene
4976
UniGene
594504
1000 Genomes
1000 Genomes
HPRD
GenAtlas
OPA1
GeneCards
OPA1