Cell Senescence Entries for ORAI1

Cell Types
Prostate cancer
Cell Lines
DU145, PC-3
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Xu et al. (2016) STIM1 accelerates cell senescence in a remodeled microenvironment but enhances the epithelial-to-mesenchymal transition in prostate cancer. Sci Rep 5(2)11754 (PubMed)

ORAI1 Gene Information

HGNC symbol
ORAI1 
Aliases
CRACM1; FLJ14466; TMEM142A 
Common name
ORAI calcium release-activated calcium modulator 1 
Entrez Id
84876
Description
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011].

ORAI1 Ontologies

Gene Ontology
Process: GO:6811; ion transport
GO:2376; immune system process
GO:6816; calcium ion transport
GO:70588; calcium ion transmembrane transport
GO:2250; adaptive immune response
GO:2115; store-operated calcium entry
GO:61180; mammary gland epithelium development
GO:70509; calcium ion import
GO:51928; positive regulation of calcium ion transport
GO:51924; regulation of calcium ion transport
GO:45762; positive regulation of adenylate cyclase activity
And 1 more GO terms
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5886; plasma membrane
GO:45121; membrane raft
GO:16323; basolateral plasma membrane
GO:32991; protein-containing complex
GO:5887; integral component of plasma membrane
GO:44853; plasma membrane raft
GO:34704; calcium channel complex
Function: GO:5515; protein binding
GO:5262; calcium channel activity
GO:42802; identical protein binding
GO:5516; calmodulin binding
GO:15279; store-operated calcium channel activity
Show all GO terms

Homologs of ORAI1 in Model Organisms

Danio rerio
LOC566671
Mus musculus
Orai1
Rattus norvegicus
Orai1

External links

OMIM
610277
Ensembl
ENSG00000276045
Entrez Gene
84876
UniGene
55148
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ORAI1
GeneCards
ORAI1