Cell Senescence Entries for P3H1

Cell Types
Lung fibroblast
Cell Lines
IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative, Stress-induced
Senescence Effect
Inhibits
Primary Reference
Succoio et al. (2016) Proteomic analysis reveals novel common genes modulated in both replicative and stress-induced senescence. J Proteomics 128(2)18-29 (PubMed)

P3H1 Gene Information

HGNC symbol
P3H1 
Aliases
GROS1; LEPRE1; LEPRECAN; MGC117314 
Common name
prolyl 3-hydroxylase 1 
Entrez Id
64175
Description
This gene encodes an enzyme that is a member of the collagen prolyl hydroxylase family. These enzymes are localized to the endoplasmic reticulum and their activity is required for proper collagen synthesis and assembly. Mutations in this gene are associated with osteogenesis imperfecta type VIII. Three alternatively spliced transcript variants encoding different isoforms have been described. Other variants may exist, but their biological validity has not been determined. [provided by RefSeq, Aug 2011].

P3H1 Ontologies

Gene Ontology
Process: GO:6457; protein folding
GO:60348; bone development
GO:8285; negative regulation of cell population proliferation
GO:50821; protein stabilization
GO:19511; peptidyl-proline hydroxylation
GO:32963; collagen metabolic process
GO:61077; chaperone-mediated protein folding
GO:1901874; negative regulation of post-translational protein modification
GO:50708; regulation of protein secretion
GO:10976; positive regulation of neuron projection development
GO:18126; protein hydroxylation
And 1 more GO terms
Cellular component: GO:16020; membrane
GO:32991; protein-containing complex
GO:5783; endoplasmic reticulum
GO:5576; extracellular region
GO:70062; extracellular exosome
GO:62023; collagen-containing extracellular matrix
GO:5788; endoplasmic reticulum lumen
GO:5737; cytoplasm
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:5506; iron ion binding
GO:16705; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:31418; L-ascorbic acid binding
GO:51213; dioxygenase activity
GO:5515; protein binding
GO:3674; molecular_function
GO:19797; procollagen-proline 3-dioxygenase activity
GO:5518; collagen binding
Show all GO terms

Homologs of P3H1 in Model Organisms

Caenorhabditis elegans
CELE_Y73F8A.26
Danio rerio
lepre1
Mus musculus
Lepre1
Rattus norvegicus
Lepre1

External links

OMIM
610339
Ensembl
ENSG00000117385
Entrez Gene
64175
UniGene
720014
1000 Genomes
1000 Genomes
HPRD
GenAtlas
P3H1
GeneCards
P3H1